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Image Search Results
Journal: Molecular Medicine Reports
Article Title: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma
doi: 10.3892/mmr.2019.10811
Figure Lengend Snippet: Differential expression analysis of microarray GSE100186. (A) Heatmap of GSE100186, in the heatmap, the green color represents low expression while the red color represents high expression. (B) Volcano plot of GSE100186. Compared with the normal group, red represents upregulated genes in the cancer group, whereas blue represents downregulated genes in the cancer group. NOT represents no change in the differential expression analysis.
Article Snippet:
Techniques: Expressing, Microarray
Journal: Molecular Medicine Reports
Article Title: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma
doi: 10.3892/mmr.2019.10811
Figure Lengend Snippet: Enrichment analysis of the circRNA-miRNA-up-regulated mRNA network. (A) Regulatory network of hub circRNAs. Arrowheads represent circRNAs, diamonds represent miRNAs and circles represent genes. (B) Dotplot of GO and KEGG enrichment analyses. circRNA, circular RNA; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; miRNA, microRNA.
Article Snippet:
Techniques:
Journal: Molecular Medicine Reports
Article Title: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma
doi: 10.3892/mmr.2019.10811
Figure Lengend Snippet: Top five GO terms and KEGG pathways enriched in the circRNA-miRNA-upregulated mRNA network.
Article Snippet:
Techniques: Activity Assay, Binding Assay
Journal: Molecular Medicine Reports
Article Title: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma
doi: 10.3892/mmr.2019.10811
Figure Lengend Snippet: Enrichment analysis of the circRNA-miRNA-downregulated mRNA network. (A) Regulatory network of hub circRNAs. Arrowheads represent circRNAs, diamonds represent miRNAs and circles represent genes. (B) Top 5 GO terms and (C) top 5 KEGG pathways, as determined by enrichment analysis. circRNA, circular RNA; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; miRNA, microRNA.
Article Snippet:
Techniques:
Journal: Molecular Medicine Reports
Article Title: Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma
doi: 10.3892/mmr.2019.10811
Figure Lengend Snippet: Top five GO terms and KEGG pathways enriched in the circRNA-miRNA-downregulated mRNA network.
Article Snippet:
Techniques: Activity Assay
Journal: Cell Death & Disease
Article Title: Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis
doi: 10.1038/s41419-019-1590-5
Figure Lengend Snippet: a Scatter plots were used to evaluate the difference in the expression of circRNAs between Ang II and control groups. The values plotted on X and Y axes are the averaged normalized signal values of each group (log2 scaled). The circRNAs above the top green line and below the bottom green line indicate >1.5-fold change between the two groups. b Hierarchical clustering analysis showed the differentially expressed circRNAs over 2.0-fold change. Red color indicates high expression level, and blue color indicates low expression level. c Divergent and convergent primers were used to verify whether circNRG-1 was a circRNA. Convergent primers were used to detect NRG-1 mRNA. Divergent primers amplified circNRG-1 in cDNA but not gDNA. GAPDH served as linear control and size marker in base pairs. d Sanger sequencing confirmed head-to-tail junction of circNRG-1. e RNA fluorescence in situ hybridization for circNRG-1 was detected. Nuclei were stained with DAPI. Scale bars = 50 μm. f qRT-PCR detected circNRG-1 expression in MASMCs treated with Ang II (10 −7 M) for the different times. Data represent the means ± SEM of three independent experiments. * P < 0.05, *** P < 0.001 vs . Ang II for 0 h
Article Snippet: Circular RNA expression profiling was performed using Arraystar
Techniques: Expressing, Control, Amplification, Marker, Sequencing, Fluorescence, In Situ Hybridization, Staining, Quantitative RT-PCR
Journal: Cell Death & Disease
Article Title: Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis
doi: 10.1038/s41419-019-1590-5
Figure Lengend Snippet: The orange, purple and green nodes represent circRNA, miRNA and mRNA respectively. Markers highlighting staining showed circNRG-1-miR-193b-5p-NRG-1 interactions
Article Snippet: Circular RNA expression profiling was performed using Arraystar
Techniques: Staining
Journal: Cancer Management and Research
Article Title: Profiles of differentially expressed circRNAs in esophageal and breast cancer
doi: 10.2147/CMAR.S167863
Figure Lengend Snippet: General information of ESCC patients for microarray test
Article Snippet: The RNA was isolated with an RNeasy mini kit (Qiagen, Hilden, Germany) and analyzed using an
Techniques: Microarray
Journal: Cancer Management and Research
Article Title: Profiles of differentially expressed circRNAs in esophageal and breast cancer
doi: 10.2147/CMAR.S167863
Figure Lengend Snippet: General information of BC patients for microarray test
Article Snippet: The RNA was isolated with an RNeasy mini kit (Qiagen, Hilden, Germany) and analyzed using an
Techniques: Microarray